The genes most commonly associated with celiac disease are the HLA-DQA1 and HLA-DQB1 genes. There is one allele of HLA-DQA1 (DQA1*05) and two alleles of HLA-DQB1 (HLA-DQB1*02 and HLA-DQB1*0302) that each increase the risk of developing celiac disease. This celiac disease genotyping analysis determines the presence or absence of these three alleles.
The Celiac Disease (HLA-DQA1 and DQB1) Genotyping Test uses high resolution Sequence Based Typing (SBT) technology to confirm an individual’s HLA-DQA1 and HLA-DQB1 genotypes. SBT testing technology is able to test whether an individual has two copies of each allele (homozygous), one copy (heterozygous) or whether an individual does not carry any of the at-risk alleles.
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