Celiac Disease DNA Test (HLA-DQA1 and HLA-DQB1)

Find out if you are at increased risk

  • Celiac disease is an autoimmune disorder triggered by gluten consumption
  • Celiac disease affects up to 1 in 100 people
  • Nearly 100% of celiac patients carry one or more of these alleles; HLA-DQA1*05, HLA-DQB1*02 and HLA-DQB1*0302
  • Having a family member with celiac disease increases your risk by 10 – 15%
  • Simple mouth swab DNA test with results in 1 – 2 weeks
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What is Celiac Disease (HLA-DQA1 and DQB1) Genotyping?

The genes most commonly associated with celiac disease are the HLA-DQA1 and HLA-DQB1 genes. There is one allele of HLA-DQA1 (DQA1*05) and two alleles of HLA-DQB1 (HLA-DQB1*02 and HLA-DQB1*0302) that each increase the risk of developing celiac disease. This celiac disease genotyping analysis determines the presence or absence of these three alleles.

The Celiac Disease (HLA-DQA1 and DQB1) Genotyping Test uses high resolution Sequence Based Typing (SBT) technology to confirm an individual’s HLA-DQA1 and HLA-DQB1 genotypes. SBT testing technology is able to test whether an individual has two copies of each allele (homozygous), one copy (heterozygous) or whether an individual does not carry any of the at-risk alleles.


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The kit can be ordered online, by fax or mail, or by phone. Once you place the order, the testing kit will be shipped directly to you. The kit contains swabs called “buccal swabs”. DNA is collected quickly and easily by rubbing the swabs inside your mouth against the cheek for 30 seconds. Once the DNA is collected, the swabs are placed into the specimen container provided in the kit and returned to the laboratory for testing using the return package included in the testing kit. Once your samples arrive at the laboratory, testing begins immediately and results are available in 1 to 2 weeks.

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Symptoms of Celiac Disease

Gastrointestinal Symptoms

The symptoms of celiac disease vary between individuals and include both gastrointestinal and non-gastrointestinal symptoms. Gastrointestinal symptoms may include:

  • Flatulence
  • Bloating
  • Constipation and/or diarrhea
  • Pale/fatty/bloody stools
  • Weight loss
  • Appetite changes
  • Nausea & vomiting

Non-Gastrointestinal Symptoms

The non-gastrointestinal symptoms of celiac disease also vary between individuals and may include:

  • Fatigue
  • Migraines
  • Irritability, depression and anxiety
  • Muscle cramps and joint pain
  • Skin rashes (dermatitis herpetiformis)
  • Growth & puberty delay
  • Tingling in legs and feet
  • Mouth ulcers and dental enamel defects
  • Seizures

Frequently Asked Questions

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The Disease

If a family member has celiac disease, am I at increased risk? How common is celiac disease? How is celiac disease diagnosed?

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Avada Admin

The Test

What are HLA-DQA1 and HLA-DQB1? What are my risks of developing celiac disease if I test positive? If I test negative, am I still at risk of developing celiac disease?

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The Results

How will I receive my results? How long will testing take? What are the possible results and what are the interpretations for each result type?

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Get Started


Are you ready to get started? Print out this form and take it to your next doctor’s appointment to initiate a conversation with your doctor about Horizon carrier screening.

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Celiac Disease Learning Center

What does my HLA genotype mean?

The celiac disease genotyping test offered by Genetrace detects three HLA variations (alleles) that are linked to an increased risk of celiac disease. Nearly 100% of celiac patients carry one or more of these alleles, [...]

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